Vasoactive Intestinal Peptide (VIP)

Buy VIP Peptide Ireland Online From Direct Sarms

Buy VIP Peptide (Vasoactive Intestinal Peptide), a powerful regulatory molecule essential for maintaining balance within the body. The 28 amino acid peptide plays a key role in supporting immune system function, reducing inflammation, and enhancing central nervous system performance.

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What is Vasoactive Intestinal Peptide (VIP)?

Vasoactive Intestinal Peptide (VIP) is a natural neuropeptide made up of 28 amino acids. Its small size allows it to interact efficiently with its receptors, playing a key role in many important biological functions.

Produced mainly in the nervous system and the gut, VIP helps reduce inflammation, control smooth muscle activity, and support digestion by regulating enzyme secretion and water and ion transport. It also supports the immune system by balancing the inflammatory response and promoting overall immune health. Additionally, its neuroprotective properties help maintain the central nervous system, making VIP important for both immune and neurological health.

How Does VIP Work?

Vasoactive Intestinal Peptide (VIP) works by attaching to specific receptors, VPAC1 and VPAC2, that manage many bodily functions. VPAC1 is located in areas like the gastrointestinal tract, heart, and lungs, while VPAC2 is found in the brain and other tissues.

Once VIP binds to these receptors, it activates pathways that control muscle relaxation, secretion, and inflammation. This process helps relax muscles, improve blood flow, aid digestion, and regulate fluid levels. VIP also supports brain function by balancing mood, sleep, and learning, while its anti-inflammatory properties protect the immune system and may safeguard against neurodegenerative diseases.

Vasoactive Intestinal Peptide Specifications

Vasoactive Intestinal Peptide (VIP) Structure — *Source: PubChem*

Molecular Formula: C147H237N43O43S

Molecular Weight: 3326.8 g/mol

Sequence: H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-OH

View our VIP High-Performance Liquid Chromatography (HPLC) Certificate here.

Buy VIP Peptide Vial 2 mg lyophilized powder (freeze dried). Before use it needs to be reconstituted with bacteriostatic water which is available to buy from Direct Sarms.

What are the suggested research benefits of Vasoactive Intestinal Peptide?

Anti-Inflammatory and Immunomodulation:

Immunosuppressive Effects: It has been shown to regulate immune responses, particularly in inflammatory conditions, by reducing the production of pro-inflammatory cytokines and promoting the development of regulatory T cells [1]. This makes it an important player in autoimmune diseases and chronic inflammation.
Protection in Autoimmune Diseases: Ireland Research studies have shown that it can alleviate symptoms in autoimmune conditions like multiple sclerosis and rheumatoid arthritis by modulating immune responses [2].

Neuroprotective Effects and Brain Health:

Cognitive Function and Neurodegenerative Diseases: Ireland Studies have demonstrated it has neuroprotective properties and is being investigated for its potential in treating neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. VIP modulates neurotransmitter release, reduces oxidative stress, and protects against neuroinflammation, which can help preserve cognitive function [3].
Mood and Sleep Regulation: It’s role in regulating circadian rhythms and mood has also been a key focus. Ireland Studies indicate it affects the brain’s internal clock, potentially offering therapeutic benefits for sleep disorders and mood disorders like anxiety and depression [4].

Cardiovascular Benefits:

Vasodilation and Blood Pressure Regulation: Ireland Research shows it acts as a potent vasodilator, helping to widen blood vessels and improve blood flow. It does this by binding to receptors (called VPAC receptors) on the smooth muscle cells lining blood vessels, leading to the relaxation of these muscles. This makes it a promising molecule for addressing conditions like hypertension and heart failure [5].

Gastrointestinal Health:

Gastrointestinal Motility: It plays a crucial role in regulating smooth muscle tone in the gastrointestinal tract, which aids in peristalsis and digestion. It helps to relax smooth muscles, promoting the movement of food and enhancing nutrient absorption [6].
Secretion of Fluids: Ireland Studies show it stimulates the secretion of fluids, such as water and electrolytes, particularly in the gastrointestinal system. This is important for processes like digestive fluid production in the intestines, aiding in digestion and absorption [7].
Treatment of Inflammatory Bowel Disease (IBD): Due to its anti-inflammatory properties, it is being explored as a potential treatment for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis [8].

Wound Healing and Skin Health

Promoting Tissue Repair: Science has demonstrated that its ability to promote cell migration, angiogenesis (formation of new blood vessels), and reduce inflammation makes it an important factor in wound healing [9].
Improving Lung Function: It plays a crucial role in maintaining optimal lung function by regulating bronchial tone and reducing airway hyperresponsiveness. Its bronchodilatory effects can help alleviate conditions such as asthma and chronic obstructive pulmonary disease (COPD). Additionally, it supports the preservation of healthy lung tissue by controlling oxidative stress and modulating immune activity, thereby contributing to overall respiratory health [10].

Metabolic Health and Obesity:

Influence on Appetite and Metabolism: According to Ireland research it has been implicated in regulating energy balance and appetite, with some research suggesting it could play a role in managing obesity and metabolic syndrome by influencing the hypothalamus and regulating food intake [11].
Potential Role in Diabetes Management: Ireland Studies have shown its impact on glucose metabolism and insulin regulation, suggesting it has potential as a therapeutic agent in managing diabetes. It may improve insulin sensitivity and reduce inflammation, which are key factors in the progression of both type 1 and type 2 diabetes [12].

Potential in Cancer Therapy

Cancer Growth Regulation: VIP’s role in modulating immune function and its effects on inflammation have sparked interest in its potential anti-cancer properties. Some Ireland studies suggest that it might inhibit the growth of certain tumor cells by promoting a more favorable immune environment [13].

What VIP products are available Ireland?

Buy VIP Peptide and BPC-157 Nasal Stack

Buy VIP Peptide and BPC-157 Nasal Stack Ireland for clinical research use from Direct Sarms, available in 15ml and 30ml bottles. This innovative stack combines the benefits of Vasoactive Intestinal Peptide, which promotes vascular health, immune modulation, and neuroprotection, with the tissue-repairing and anti-inflammatory properties of BPC-157.

Buy VIP Peptide Pre-Mixed Pen 2 mg

Buy VIP Peptide Pre-Mixed Pen 2mg Ireland for research from Direct Sarms. The VIP pre-mixed pen 2 mg peptide provides a precise, convenient way to deliver Vasoactive Intestinal Peptide (VIP). This high purity pre-mixed formulation contains VIP in the correct concentration for immediate use, eliminating the need for manual preparation and reducing the risk of dosage errors.

Frequently Asked Questions (FAQ’s) about Vasoactive Intestinal Peptide

Is VIP peptide legal?

The legal status of Vasoactive Intestinal Peptide depends on the country and how it’s being used. In most cases, it’s classified as a research chemical and isn’t approved for general medical or therapeutic use. This means it can be used for scientific research but isn’t usually available for human treatment unless authorised by regulatory bodies like the FDA in the U.S. or the MHRA in the U.K. Before you buy VIP peptides, make sure to check your local laws and guidelines to stay compliant.

Are there any known side effects in therapy?

While research into therapy is still emerging, side effects may vary depending on the method of administration and individual response. Clinical trials are crucial in determining its safety and efficacy for widespread use.

Is VIP naturally present in the body?

It is produced naturally in the human body, primarily in the gut, pancreas, and neurons. It is essential for maintaining various bodily functions.

How does VIP impact overall health?

It has multiple beneficial effects on health. It supports immune system regulation, helps maintain proper glucose metabolism, reduces inflammation, and relaxes smooth muscles in organs like the lungs and digestive tract.

What triggers the release of VIP?

The release of VIP is typically stimulated by various physiological and environmental factors. For instance, food intake can activate its release in the digestive system to aid in processes such as relaxing intestinal muscles and regulating blood flow. Additionally, stress and certain nerve signals can trigger the secretion of VIP, as it plays a role in modulating immune responses and maintaining homeostasis in the body. Research continues to explore the full range of triggers for VIP release and its intricate role in human health.

Buy VIP Peptide Today!

Buy VIP peptide from Direct Sarms, available in multiple formulations to support laboratory and clinical research. Options include nasal sprays for non-invasive use, vials of lyophilized powder for subcutaneous injections, pre-mixed pens with peptides combined with bacteriostatic water, and stacks with other peptides for enhanced effects.

When you buy VIP peptide, it’s essential to choose trusted suppliers like Direct Sarms to guarantee quality and purity. Reliable Vasoactive Intestinal Peptide is key for accurate research, especially due to its role in complex biological systems. Direct Sarms provides fast shipping, secure packaging, and competitive pricing to support researchers effectively.

Scientific References

[1] M Delgado, C Abad, C Martinez, M G Juarranz, et al (2002) Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases – Journal of Molecular Medicine (Berl), 2002 Jan, Volume 80 (Issue 1), Pages 16-24.

[2] Amelia Fernandez-Martin, Elena Gonzalez-Rey, Alejo Chorny, Javier Martin, et al (2006) VIP prevents experimental multiple sclerosis by downregulating both inflammatory and autoimmune components of the disease – Annals of New York Academy of Sciences, 2006 Jul, Volume 1070, Pages 276-81.

[3] Mario Delgado and Doina Ganea (2003) Vasoactive intestinal peptide prevents activated microglia-induced neurodegeneration under inflammatory conditions: potential therapeutic role in brain trauma – FASEB Journal, 2003 Oct, Volume 17 (Issue 13), Pages 1922-4.

[4] Dawn H Loh, Catalina Abad, Christopher S Colwell, James A Waschek (2008) Vasoactive intestinal peptide is critical for circadian regulation of glucocorticoids – Neuroendocrinology, 2008, Volume 88 (Issue 4), Pages 246-55.

[5] Robert J Henning and Darrell R Sawmiller (2001) Vasoactive intestinal peptide: cardiovascular effects – Cardiovascular Research, Volume 49, Issue 1, January 2001, Pages 27–37.

[6] Xiaopeng Bai, Giada De Palma, Elisa Boschetti, Yuichiro Nishiharo, et al (2024) Vasoactive Intestinal Polypeptide Plays a Key Role in the Microbial-Neuroimmune Control of Intestinal Motility – Cellular & Molecular Gastroenterology & Hepatology, 2024, Volume 17 (Issue 3), Pages 383-398.

[7] Mari Iwasaki, Yasutada Akiba, and Jonathan D Kaunitz (2019) Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system – F1000 Research, 2019 Sep 12, Volume 8, F1000 Faculty Rev-1629.

[8] Xiong Sun, Yao Huang, Ya-Li Zhang, Dan Qiao, and Yan-Cheng Dai (2020) Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells – World Journal of Gastroenterology, 2020 Dec 28, Volume 26 (Issue 48), Pages 7593–7602.

[9] Liu Shi, Yang Liu, Zhengmeng Yang, Tianyi Wu, et al (2021) Vasoactive Intestinal Peptide Promotes Fracture Healing in Sympathectomized Mice – Calcified Tissue International, 2021 Jul, Volume 109 (Issue 1), Pages 55-65.

[10] Cha-Xiang Guan, Min Zhang, Xiao-Qun Qin, Yan-Ru Cui, et al (2006) Vasoactive intestinal peptide enhances wound healing and proliferation of human bronchial epithelial cells – Peptides, 2006 Dec, Volume 27 (Issue 12), Pages 3107-14.

[11] John P Vu, Muriel Larauche, Martin Flores (2015) Regulation of Appetite, Body Composition, and Metabolic Hormones by Vasoactive Intestinal Polypeptide (VIP) – Journal of Molecular Neuroscience, 2015 Jun, Volume 56 (Issue 2), Pages 377-87.

[12] Xintong Hou, Dan Yang, Guimei Yang, Mengnan Li, et al (2022) Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes – Frontiers in Endocrinology (Lausanne), 2022 Sep 20, Volume 13, Page 984198.

[11] Masaki Hara, Yuko Takeba, Taroh Iiri, Yuki Ohta, et al (2018) Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl‐xL pathway – Cancer Science, 2018 Dec 4, Volume 110 (Issue 1), Pages 235–244.

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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